Fetal hemoglobin - Wikipedia - fetal hemoglobin vs adult hemoglobin


Switching from fetal to adult hemoglobin | Nature Genetics fetal hemoglobin vs adult hemoglobin

Fetal hemoglobin, or foetal haemoglobin is the main oxygen transport protein in the human fetus during the last seven months of development in the uterus and persists in the newborn until roughly months old. Functionally, fetal hemoglobin differs most from adult hemoglobin in that it is pO2, is left-shifted for fetal hemoglobin as compared to adult hemoglobin.

The fetal-to-adult hemoglobin switch and silencing of fetal hemoglobin (HbF) . regulation of the primate β-globin gene cluster compared with that of humans.

The gamma subunit differs from its adult counterpart in that it contains The P50 for fetal hemoglobin is 19mm Hg, compared to 27 for HbA.

Fetal hemoglobin (HbF) is the predominant form of hemoglobin These differences specifically alter BPG binding to HbF as compared to HbA.

Fetal hemoglobin binds to oxygen more strongly than adult hemoglobin, . 21 mm Hg compared to a P50 of 27 mm Hg observed in adults (see Fig ),14 .